abstract：:The HLA-DR4 subtypes Dw14 and Dw4 are T-cell-defined allospecificities encoded by the DRB1*0404 and DRB1*0401 genes, respectively. Although these allelic subtypes differ in only two amino acids, allorecognition between Dw14 and Dw4-positive individuals is brisk. This provides an opportunity to analyze T-cell receptor ...

journal_title：Human immunology

authors： Yamanaka K,Kwok WW,Mickelson EM,Masewicz S,Nepom GT

更新日期：1992-01-01 00:00:00

abstract：:Juvenile dermatomyositis (JDMS) is an inflammatory disease associated with HLA-DR3. We therefore undertook molecular genetic studies of HLA region genes to determine whether HLA-DR3 itself confers susceptibility to JDMS or whether susceptibility is conferred by alleles in linkage disequilibrium with HLA-DR3. Our resul...

journal_title：Human immunology

authors： Reed AM,Pachman L,Ober C

更新日期：1991-12-01 00:00:00

abstract：:We have constructed the detailed physical map of the HLA class II gene region by the pulsed field gel electrophoresis (PFGE) and cosmid walking technique. In this process, the DNA gene was found to be located telomeric to DPA1 with the 5'----3' orientation which is the same as the DPA1 and DPA2 genes, but opposite to ...

journal_title：Human immunology

authors： Okamoto N,Ando A,Kawai J,Yoshiwara T,Tsuji K,Inoko H

更新日期：1991-11-01 00:00:00

abstract：:The HLA-DR4 haplotype consists of four DRB genes: DRB1*04, DRBVII, DRBVIII, and DRB4*01, arranged in this order on the chromosome. The DRB1 and DRB4 genes code for beta chains of the alpha beta heterodimers expressed on the cell surface and bearing the HLA-DR4 and HLA-DRw53 determinants, respectively; the DRBVII and D...

journal_title：Human immunology

authors： Klein D,Vincek V,Kasahara M,Schönbach C,O'hUigin C,Klein J

更新日期：1991-11-01 00:00:00

abstract：:The multidrug resistance gene (mdr1) is a member of the recently described ATP binding cassette (ABC) superfamily of transporters. Family members include: (1) the cystic fibrosis transmembrane conductance regulator gene; (2) the hlyB gene of bacteria, and (3) the histocompatibility antigen modifier (HAM) gene. The lev...

journal_title：Human immunology

authors： Coon JS,Wang YZ,Bines SD,Markham PN,Chong AS,Gebel HM

更新日期：1991-10-01 00:00:00

abstract：:Screening of a human cosmid library representing genomic DNA from an individual homozygous for the HLA-DR2 B7 A2 haplotype yielded 109 class I HLA-specific clones. One cosmid clone, Ice 6.23, had a full-length nonclassical class I gene within a 5.4-kb HindIII fragment. The Ice 6.23-5.4H gene was cloned into the unique...

journal_title：Human immunology

authors： Pook MA,Woodcock V,Tassabehji M,Campbell RD,Summers CW,Taylor M,Strachan T

更新日期：1991-10-01 00:00:00

abstract：:Felty's syndrome (FS) is a rare complication of rheumatoid arthritis (RA) previously shown to be strongly associated with HLA-DR4 and less significantly with HLA-DQw7. To map more precisely the HLA locus responsible for susceptibility to FS, we have examined HLA-DR4 and DQ beta-chain polymorphisms in FS patients and c...

journal_title：Human immunology

authors： Lanchbury JS,Jaeger EE,Sansom DM,Hall MA,Wordsworth P,Stedeford J,Bell JI,Panayi GS

更新日期：1991-09-01 00:00:00

abstract：:Many factors induce or enhance expression of major histocompatibility complex class I and class II molecules on various cell types. Human T lymphocytes are class II negative in the resting state but show expression of class II molecules following activation. We analyzed the modulating capacity of the lymphokines recom...

journal_title：Human immunology

authors： Diedrichs-Möhring M,Epplen JT,Schendel DJ

更新日期：1991-08-01 00:00:00

abstract：:The reactivity of monoclonal antibodies (mAbs) R1, S1, and S5, shown previously to recognize polymorphic epitopes on HLA-DQ molecules, have been found to correlate with the presence of certain DQB1 alleles. mAb S5 reacts with cells expressing DQB1*0503, 0601, 0602, 0603, or 0604 alleles while R1 and S1 react with all ...

journal_title：Human immunology

authors： Nordwig H,Kwok WW,Johnson JP

更新日期：1991-06-01 00:00:00

abstract：:Minor lymphocyte stimulating locus (Mls) gene products in association with mouse major histocompatibility complex (MHC) class II molecules are known to determine the repertoire of T-cell receptor (TCR) in mature T cells. In order to test whether human class II molecules can present mouse Mls, HLA-DQ beta transgenic mi...

journal_title：Human immunology

authors： Zhou P,Anderson GD,Savarirayan S,Inoko H,David CS

更新日期：1991-05-01 00:00:00

abstract：:From 535 endomyocardial biopsies (87 heart transplant recipients) 283 cell cultures could be generated. All cultures tested contained T lymphocytes and in most cases CD4 was the predominant phenotype at any time posttransplant. A significantly higher proportion of CD8-dominated cultures was found among cultures from b...

journal_title：Human immunology

authors： Ouwehand AJ,Vaessen LM,Baan CC,Jutte NH,Balk AH,Essed CE,Bos E,Claas FH,Weimar W

更新日期：1991-01-01 00:00:00

abstract：:A certain HLA-DQA2 locus TaqI fragment, DX alpha"U", has been reported to be associated with insulin-dependent diabetes mellitus (IDDM). Reports of various studies in this vein have ranged from stating that the association of DQA2"U" with IDDM exists even among subjects positive for HLA-DR3 and -DR4 to stating that th...

journal_title：Human immunology

authors： Rowe JR,Neme de Gimenez MH,Emler CA,Sheehy MJ

更新日期：1990-12-01 00:00:00

abstract：:This study describes the diversity of DRw6 and DR5 haplotypes in the American black population using serology, cellular typing, and restriction fragment length polymorphism (RFLP) analysis. DRw6 (DRw13 and DRw14) and DR5 (DRw11 and DRw12) haplotypes are observed at a high frequency in this population (DRw6: 32%, DR5: ...

journal_title：Human immunology

authors： Lee KW,Hurley CK,Hartzman R,Johnson AH

更新日期：1990-11-01 00:00:00

abstract：:A panel of 34 clones was established from a cell line derived from the skin biopsy of a patient (genotype: A1, A2, B7, B8, DR3, DR6) undergoing acute graft-versus-host disease after semiallogeneic bone marrow transplantation with his mother's bone marrow (genotype: A1, A1, B7, B8, DR3, DR6). The T-cell line obtained p...

journal_title：Human immunology

authors： Vié HP,Millpied N,Devilder MC,Mahe B,Hallet MM,Moreau JF,Soulillou JP

更新日期：1990-10-01 00:00:00

abstract：:Of 188 cases of Kaposi's sarcoma arising de novo after transplantation, HLA-A, -B typing was available for 135 and HLA-DR typing available for 67. Compared to the reported HLA phenotype frequencies of renal transplant recipients in the Southeast Organ Procurement Foundation (SEOPF), there is a significantly decreased ...

journal_title：Human immunology

authors： Brunson ME,Balakrishnan K,Penn I

更新日期：1990-09-01 00:00:00

abstract：:HLA-Dw 19 antigen presenting cells express two different DR beta chains encoded respectively by DRB1 and DRB3 genes. In the present study we determined which of these two DR beta chains is recognized by DR-restricted T-cell clones. First we selected influenza-specific, DR-restricted T-cell clones of which restriction ...

journal_title：Human immunology

authors： Zeliszewski D,Tiercy JM,Dorval I,Kaplan C,Mach B,Sterkers G

更新日期：1990-08-01 00:00:00

abstract：:The pattern of lymphocyte growth from endomyocardial biopsies in 55 heart transplant recipients was shown to be correlated with the subsequent development of graft coronary disease. Persistent lymphocyte growth was observed in 39 patients, and 15 of these growers (or 41%) developed graft coronary disease. In contrast,...

journal_title：Human immunology

authors： Kaufman CL,Zeevi A,Kormos RL,Zerbe TR,Keenan RJ,Uretsky BF,Griffith BP,Hardesty RL,Duquesnoy RJ

更新日期：1990-06-01 00:00:00

abstract：:Tumor-infiltrating lymphocytes (TIL) freshly isolated from human ovarian carcinomas were phenotyped (up to 75% CD3+ HLA-DR+ cells) and cultured in the presence of recombinant interleukin 2 and tumor necrosis factor alpha. In short-term cultures, an initial outgrowth of CD3+ CD8+ T lymphocytes resulted in the enrichmen...

journal_title：Human immunology

authors： Vaccarello L,Wang YL,Whiteside TL

更新日期：1990-06-01 00:00:00

abstract：:We have investigated if recombinant granulocyte-macrophage colony stimulating factor (GM-CSF), alone or in concert with recombinant gamma interferon, affects the endothelial cell expression of class I major histocompatibility complex antigen. Results obtained show that the GM-CSF increases class I expression on the en...

journal_title：Human immunology

authors： Leszczynski D,Häyry P

更新日期：1990-06-01 00:00:00

abstract：:CD4+ T cells were cultured from posttransplant cardiac biopsies placed on irradiated feeder cells of autologous cloned donor major histocompatibility complex class II-specific T-cell lines cultured and grown from previous biopsies. Fourteen of the CD4+ T-cell cultures were expanded and cloned using the same feeder cel...

journal_title：Human immunology

authors： Wang YC,Kanter K,Lattouf O,Rodey GE,Sell KW,Ansari AA

更新日期：1990-06-01 00:00:00

abstract：:The HLA-DRB3 gene, which encodes the supertypic HLA-DRw52 antigen, has been shown to have limited polymorphism. The alleles at this locus are also in linkage disequilibrium with the alleles at the DRB1 locus. We have studied 16 DRw11 and three DRw12 haplotypes in the South African populations. Five of the DRw11,DQw7 h...

journal_title：Human immunology

authors： Martell RW,Oudshoorn M,Arendse B,du Toit ED

更新日期：1990-05-01 00:00:00

abstract：:We have investigated the distribution of genotypes of a restriction fragment length polymorphism of the T-cell receptor beta-subunit gene in Caucasoid controls and patients with insulin-dependent diabetes mellitus, celiac disease, dermatitis herpetiformis, and idiopathic membranous nephropathy and also in South Indian...

journal_title：Human immunology

authors： Niven MJ,Caffrey C,Moore RH,Sachs JA,Mohan V,Festenstein H,Hoover ML,Hitman GA

更新日期：1990-04-01 00:00:00

abstract：:The propensity for narcolepsy, a clinical sleep disorder of unknown etiology, is virtually totally included within the HLA-DR2,DQw1 (DRw15,DQw6) phenotype. The disorder is characterized by decreased sleep latency, early onset of rapid eye movement sleep, and a paucity of nocturnal slow-wave sleep. Muramyl peptides, na...

journal_title：Human immunology

authors： Silverman DH,Sayegh MH,Alvarez CE,Johnson TS,Milford EL,Karnovsky ML

更新日期：1990-03-01 00:00:00

abstract：:The alloimmunization against the platelet PL-A1 antigen is strongly associated with a HLA class II structure in mothers of thrombocytopenic neonates. Most of the immunized women have first been shown to possess the DR3 specificity and subsequently the DRw52 allele. The 18 immunized mothers studied here by restriction ...

journal_title：Human immunology

authors： Valentin N,Vergracht A,Bignon JD,Cheneau ML,Blanchard D,Kaplan C,Reznikoff-Etievant MF,Muller JY

更新日期：1990-02-01 00:00:00

abstract：:DNA sequences that distinguish the subsets of HLA-DR4 are also found on several other alleles. This makes typing of heterozygotes with oligonucleotide probes quite impractical. We have therefore developed a procedure in which, in a first step, DNA of the genes to be analyzed is amplified selectively, using group-speci...

journal_title：Human immunology

authors： Gao XJ,Fernandez-Vina M,Shumway W,Stastny P

更新日期：1990-01-01 00:00:00

abstract：:In the present study Latin-American celiac disease patients were analyzed for the frequency of certain HLA class II restriction fragment length polymorphisms in order to investigate whether they exhibited the normal associated alleles or showed unusual class II variants. A DPB/RsaI 4.0-kb fragment that was shown to be...

journal_title：Human immunology

authors： Herrera M,Chertkoff L,Palavecino E,Mota A,Guala MC,Fainboim L,Satz ML

更新日期：1989-12-01 00:00:00

abstract：:The exon 2 nucleotide sequences of HLA-DQwl-associated and DQw3-associated HLA-DR"Br" alleles were determined from genomic DNA amplified by the Taq polymerase chain reaction technique. Both alleles reveal identical exon 2 nucleotide sequences. Comparison with other DR alleles suggests that DR"Br" may have originated f...

journal_title：Human immunology

authors： Bidwell JL,Bidwell EA,Sansom DM,Klouda PT,Bradley BA

更新日期：1989-11-01 00:00:00

abstract：:The HLA-B5,B35 cross-reacting group is a large and serologically complex antigen family which includes the World Health Organization-recognized specificities HLA-B5,B51,Bw52,B35,Bw53,B18,Bw70,Bw71, and Bw72. In addition, several variants of antigens in this cross-reacting group have been described in the past but have...

journal_title：Human immunology

authors： Ward FE,Stewart AD,Ruiz RE,Killian P,Amos DB,Johnson AH,Kostyu DD

更新日期：1989-11-01 00:00:00

abstract：:LEW strain rats received BN strain renal allografts and were treated with daily injections of 100 micrograms BWH-4, a new IgG2a mouse anti-rat CD4 monoclonal antibody, intravenously for 5 to 10 days. These animals had a median actuarial survival of 28 days. Control animals rejected their grafts and died of uremia betw...

journal_title：Human immunology

authors： Sayegh MH,Kut JP,Milford EL

更新日期：1989-10-01 00:00:00

abstract：:Rheumatoid arthritis is associated with HLA-DR4 in several ethnic groups. Since DR4 haplotypes encode a diverse array of class II molecules, it is of interest to characterize the nature of the primary association. We have examined molecular polymorphisms of HLA class II gene products expressed by normals and rheumatoi...

journal_title：Human immunology

authors： Lanchbury JS,Sakkas LI,Marsh SG,Bodmer JG,Welsh KI,Panayi GS

更新日期：1989-09-01 00:00:00

abstract：:The intriguing observation made by Geczy et al. (1) showing the possibility of generating specific ankylosing spondylitis--cytotoxic T lymphocytes by presenting HLA-B27+AS+ cells as antigen-specific stimulator cells prompted us (by using Geczy's approach) to identify cytotoxic T lymphocytes specific for this apparent ...

journal_title：Human immunology

authors： Breur-Vriesendorp BS,Post FA,de Waal LP,Blokland E,Pool J,van der Linden S,Dekker-Saeys BJ,Goulmy E,Ivanyi P

更新日期：1989-07-01 00:00:00

abstract：:Patterns of BglII, MspI, and TaqI DP alpha and DP beta hybridizing restriction fragment length polymorphisms are compared with primed lymphocyte typing--determined specificities in 28 10th International Histocompatibility Workshop core cell lines. Correlation of specific RFLP patterns with most recognized DP types is ...

journal_title：Human immunology

authors： Easteal S,Voorhoeve AH,Zimmet P,Serjeantson SW

更新日期：1989-07-01 00:00:00

abstract：:The complete DNA sequence of a DR beta chain cDNA encoding the DRw12 allele has been determined. The sequence of this DRB1 allele reveals a structural relationship to the group of other DRB1 genes found on DRw52 haplotypes, such as DR3, -w11, -w13, -w14, and -w8. The structural similarities among this group of alleles...

journal_title：Human immunology

authors： Navarrete C,Seki T,Miranda A,Winchester R,Gregersen PK

更新日期：1989-05-01 00:00:00

abstract：:Human narcolepsy is almost exclusively associated with the major histocompatibility complex (MHC) class II antigen HLA-DR2 and is the strongest HLA-disease association described to date. Canine narcolepsy resembles the human disease in its behavioral manifestations and responses to therapeutic drugs. Therefore, mixed ...

journal_title：Human immunology

authors： Dean RR,Kilduff TS,Dement WC,Grumet FC

更新日期：1989-05-01 00:00:00

abstract：:Rearrangements of the T-cell Rearranging Gene (TRG) or T-cell-receptor gamma-chain genes were analyzed in 24 in vivo-sensitized alloreactive T-cell clones. This analysis represents the first complete assignment of TRG gene rearrangements to given variable and joining gene segments in nonleukemic T cells and provides s...

journal_title：Human immunology

authors： Moisan JP,Bonneville M,Bouyge I,Moreau JF,Soulillou JP,Lefranc MP

更新日期：1989-02-01 00:00:00

abstract：:Genetic variation of the DQ alpha and beta and of the DX alpha genes, detectable as RFLP in genomic DNA digests, has been suggested to improve the identification of individuals at high risk for insulin-dependent diabetes mellitus (IDDM). DNA from all members of 32 IDDM multiplex families was digested with six restrict...

journal_title：Human immunology

authors： Carrier CM,Mollen N,Rothman WC,Rodriguez de Cordoba S,Rey-Campos J,Ginsberg-Fellner F,Carpenter C,Rubinstein P

更新日期：1989-01-01 00:00:00

abstract：:Previously we have shown that the supratype HLA B17 BfS C4A6 B1 DR7 (17 6 1 7) carrying a C4/Bgl II RFLP correlating with C4A6 coexists in whites and Thai/Chinese. Using conventional and PFGE/Southern blotting with class II, class III, and TNF probes as well as serologic DQ subtyping, we have extended these comparison...

journal_title：Human immunology

authors： Kay PH,Dawkins RL,Williamson J,Tokunaga K,Christiansen FT,Charoenwong P

更新日期：1988-09-01 00:00:00

abstract：:In order to characterize directly the T-cell repertoire utilized in human renal allograft rejection, we analyzed 20 long-term T-cell lines established from lymphocytic infiltrates present in renal tissue obtained by needle biopsy from transplant patients with rejection indications. All cell lines are strongly cytotoxi...

journal_title：Human immunology

authors： Miceli MC,Barry TS,Finn OJ

更新日期：1988-07-01 00:00:00

abstract：:Cell-mediated cytotoxicity involves a localized secretory process in which lytic agents stored in specialized granules of the effector cells are released upon contact with the appropriate target cell membrane and cause membrane damage. The protonophore carbonylcyanide m-chlorophenylhydrazone (CCCP) inhibits cytotoxici...

journal_title：Human immunology

authors： McKinnon KP,Dunlevy JR,Dawson JR,Argon Y

更新日期：1988-06-01 00:00:00

abstract：:The monoclonal antibodies (MoAbs) KS3 and KS4 are secreted by hybridomas constructed with splenocytes from a BALB/c mouse sequentially immunized with the cultured lymphoid cells JKu and LG-2 which share only the HLA-B27 specificity. Serologic and immunochemical assays have shown that the two MoAbs recognize the same (...

journal_title：Human immunology

authors： Sakaguchi K,Ono R,Tsujisaki M,Richiardi P,Carbonara A,Park MS,Tonai R,Terasaki PI,Ferrone S

更新日期：1988-03-01 00:00:00